If the ticket is nonrefundable, then more than likely you can/should get a credit for the portion which you didn't use, then use it for another trip and possibly pay the penalty. If your son has documentation that he did have surgery, you can ask AA if you show proof of the surgery and when it took place, will they waive the change fee and just reissue the ticket, and give you a credit on the difference. That's normally how I do it and it usually works with no issues. But I don't deal with AA that much, so I'm not sure how they will handle it. Best of luck to you.
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